PHAR40050 Drug Discovery and Development I

Academic Year 2019/2020

Topics covered:-
- High throughput screening and Hit-to-Lead
- Pharmacokinetic and pharmacology issues in discovery and development
- Clinical trials and case studies
- Pro-drugs- Challenges in drug development
- The role of information- genomics, bioinformatics
- Systems Pharmacology- predicting drug-drug interactions in drug development.
- The rise of biopharmaceuticals
- Delivery of biotech molecules
- Gene delivery using viral and non-viral vectors
- Clinical development from Phase 1-Phase 3 with case studies
- Assessing drug safety using modern toxicology methods
- The role of post-marketing surveillance-personalised medicine
- Investment in biotechnology by venture capital companies

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Curricular information is subject to change

Learning Outcomes:

On successful completion of this module students should be able to:
-Describe the development process from discovery of a molecule to administration as a medicine to patients
-Be able to discuss rational drug design and high throughput screening
-What are the safety requirements needed before a drug can be approved?
-Understand the role of post-marketing surveillance
-Cite clinical trial case studies of recent drugs that have been approved for major diseases
-Cite examples of drug delivery technologies for non-injected peptide delivery
-Be able to compare viral and non-viral technologies for gene and siRNA delivery
-Know the requirements and outputs examined for clinical trials in Phases 1-4
-Be able to write an essay on attrition causes in clinical development and possible remedies
-Understand the role of -omics and systems pharmacology in modern discovery and development programmes

Student Effort Hours: 
Student Effort Type Hours


Autonomous Student Learning




Approaches to Teaching and Learning:
lectures; Q & A in lectures, private reading of assigned texts with page numbers, and up-to-date research pdfs. Access to an external expert in Venture Capital for career advice. 
Requirements, Exclusions and Recommendations
Learning Requirements:

Ideally, students should be familiar with basic pharmacokinetics and pharmacodynamics to get the most from the module. However, we will do some recapping in the event that there are attendees from non-pharmacology backgrounds.

Learning Recommendations:

Biomedical undergraduate modules in pharmacology, biochemistry and physiology taught in science, medicine or veterinary to 3rd year level. Undergraduate chemists with an interest in the drug development process would be welcome. MSc students in Biotechnology are welcome to attend. Undergrad medicinal chemists are especially welcome and usually achieve good outcomes.

Module Requisites and Incompatibles
PHAR40150 - Drug Delivery & Clinical Trial

Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Examination: End of Semester Written Examination submitted remotely over a 5 day period. It comprises two essays with a 1500 word count each, no choice, and must be submitted in Word. Week 12 Yes Standard conversion grade scale 40% Yes


Carry forward of passed components
Resit In Terminal Exam
Autumn Yes - 2 Hour
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment

How will my Feedback be Delivered?

Exam writing guide to be presented to students ahead of exam. Going over scripts post-exam with individual students. Availability to meet students ahead of exam.

Rang, HR. Drug Discovery and Development, 2nd Ed. Elsevier.
Name Role
Professor Orina Belton Lecturer / Co-Lecturer
Timetabling information is displayed only for guidance purposes, relates to the current Academic Year only and is subject to change.  
Lecture Offering 1 Week(s) - 20, 21, 22, 23 Thurs 09:00 - 09:50
Lecture Offering 1 Week(s) - 20 Tues 09:00 - 09:50
Lecture Offering 1 Week(s) - 21, 22, 23 Tues 09:00 - 09:50
Lecture Offering 1 Week(s) - 20, 21, 22, 23 Wed 14:00 - 14:50