On successful completion of the module, students should have:-

1. Improved their biomedical knowledge by being able to:-
(a). Understand the principles of tumour classification and terminology, tumour characteristics and tumour progression (invasion and metastasis).
(b). Outline the causes of cancer including viral, chemical and physical carcinogenesis and hereditary predisposition.
(c). Outline and discuss the biochemical, molecular and genetic basis (oncogenes/tumour suppressor genes) of neoplasia and the points of possible therapeutic intervention
(d). Outline and discuss the pathology of benign and malignant breast lesions, neoplasms of bone, soft tissue, skin and childhood tumours
(e). Outline the underlying principles, modes of action, pharmacokinetics, pharmacodynamics and major side effects of specific chemotherapeutic, biotherapeutic and other anti-neoplastic agents and evaluate their use in treating neoplastic disease
(f). Describe the pathology of common multi-system autoimmune diseases including rheumatoid disease and connective tissue diseases and discuss extracellular pathology and the pathology associated with ageing.
(g). Outline the principles underlying tissue transplantation and the immunologic basis and pathologic features of rejection.
(h). Outline the mode of action, pharmacokinetics, pharmacodynamics, principal side effects and major applications of the immunosuppressive agents.
(i). Outline the mode of action, pharmacokinetics, pharmacodynamics, principal side effects and major applications of the anti-inflammatory agents.

2. Improved their clinical and investigative skills by being able to
(a). Formulate an approach to the differential diagnosis, prognostic evaluation and management of neoplastic disease and outline and discuss the medical issues for the care of the cancer patient.

(b). Formulate an approach to the diagnosis, laboratory investigation and treatment of autoimmune and multisystem diseases and transplant rejection.

3 Improved their professional and personal skills by
(a). Observing and assimilating the professional attitudes of the oncologist, clinical pharmacologist, immunologist and pathologist as they provide clinical illustrations of disease.
(b). Appreciating the integral importance of Multidisciplinary Team (MDT) approaches to the delivery of personalised patient care.

Students are required to have a background in human physiology and biochemistry

AND to have a module / combination of modules with equivalent learning outcomes such as PATH30080 Disease Mechanisms and Pharmacological Principles.

Specifically, students are required to have studied modules covering cellular and tissue responses to injury, cell death, inflammation, and human immunology

PHAR 30100

Students wishing to register for this module as an Elective must please contact the Module Coordinator.

• Group/class feedback, post-assessment

Towards the end of this module, there will be a formative assessment covering the styles of questions to be expected on the exit examination.