NEUR30080 Neuromuscular and Membrane Biology

Academic Year 2019/2020

This module forms part of the core curriculum for the B.Sc. Neuroscience degree. This module is designed to give an in-depth knowledge of structure and function of neurons, neuronal communication and muscle. Major topics include a) The detailed structure of neurones and muscle cells, b) The biophysical membrane properties of these cells, c) Ion fluxes and permeabilities, d) Synaptic transmission, e) Excitation/contraction coupling and cell signaling. Parallel computer simulated practical classes will complement the lecture material in addition to physiological practicals on muscle function and EMG measurements conducted in the practical class.

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Curricular information is subject to change

Learning Outcomes:

On completion of this module students should be able to understand:1. Ion fluxes that generate the resting membrane potential of neurones and muscle cells. 2. The electrical properties of nerve and muscle cells and cannabinoid signalling..3. Synaptic communication between neurones and muscle cells.4. The physiology of excitiation contraction coupling.5. Provide experience of computer aided learning, basic physiological experimentation and recording in membrane neuroscience and of writing laboratory reports in a clear and scientific manner.

Indicative Module Content:

Properties of Ion Channels; Electrical properties of nerve cells; Neural homeostasis; Electrical signalling in neurons; The neuromuscular junction; Synaptic transmission; Mechanisms of smooth and striated muscle contractility; Neurotransmitter release mechanisms; Snare complexes; Myesthemia gravis, tetanus and botulism; Cannabinoid modulation of synaptic transmission, Protein Synthesis in the Nervous system; Microtubules and molecular motors; signaling with in neurons; Signaling within the neuron; Principles of patch clamping

Practical classes on Hands on measurements of EMG,
Meta neuron (simulating electrical and synaptic activity in nerve cells.
Group presentations on topics related to the course

Student Effort Hours: 
Student Effort Type Hours
Lectures

24

Tutorial

3

Practical

15

Specified Learning Activities

10

Autonomous Student Learning

58

Total

110

Approaches to Teaching and Learning:
The course is delivered via a series of lectures. Within lectures there are links to learning tools and animations that students are encouraged to study at home. Practical classes are provided to compliment the lectures. The EMG is a hands on practical with student participation. Students usually work in pairs. Meta Neuron is a computer based practical which can also be accessed off the campus. Students usually work in pairs to foster discussion of data.
The calls is also assigned a group presentation on topics relevant to the course. Students work in groups of 5-6 to present a 10 minute power point presentation. This fosters group interaction and helps to improve presentation skills.
There are also tutorials in class which are problem based. 
Requirements, Exclusions and Recommendations
Learning Recommendations:

Students should have prior learning in modules such as PHYS10020 or equivalent.


Module Requisites and Incompatibles
Equivalents:
Membrane biology (BMOL30080), Membrane biology (PHYS30130)

 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Examination: written examination on the lecture course
Three questions out of four
2 hour End of Trimester Exam No Graded No

70

Lab Report: Practical class write-ups, class group presentations
MCQ exam
Varies over the Trimester n/a Graded No

30


Carry forward of passed components
Yes
 
Resit In Terminal Exam
Spring Yes - 2 Hour
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment
• Group/class feedback, post-assessment

How will my Feedback be Delivered?

Reports are handed in, graded and available to look at when graded. There will be comments made on the graded report.. MCQ: No feed back is provided. Group presentation. Feed back is provided at the presentation to the whole group.

Neuroscience 5th Edition. Editors: Purves, Augustine, Fitzpatrick, Hall, LaMantia and White. Publisher Sinauer

Essentials of Neural Science and Behaviour Editors: Kandel, Schwartz and Jessell Publisher Appelton and Lange
Name Role
Dr Andrew Irving Lecturer / Co-Lecturer
Professor John O'Connor Lecturer / Co-Lecturer
Dr Niamh O'Sullivan Lecturer / Co-Lecturer
Timetabling information is displayed only for guidance purposes, relates to the current Academic Year only and is subject to change.  
Autumn
     
Lecture Offering 1 Week(s) - Autumn: All Weeks Thurs 16:00 - 16:50
Lecture Offering 1 Week(s) - Autumn: All Weeks Tues 15:00 - 15:50
Practical Offering 1 Week(s) - 10 Wed 10:00 - 11:25
Practical Offering 1 Week(s) - 2 Wed 10:00 - 11:25
Practical Offering 1 Week(s) - 4 Wed 10:00 - 11:25
Practical Offering 1 Week(s) - 6 Wed 10:00 - 11:25
Practical Offering 1 Week(s) - 8 Wed 10:00 - 11:25
Practical Offering 2 Week(s) - 10 Thurs 10:00 - 11:25
Practical Offering 2 Week(s) - 2, 8 Thurs 10:00 - 11:25
Practical Offering 2 Week(s) - 4 Thurs 10:00 - 11:25
Practical Offering 2 Week(s) - 6 Thurs 10:00 - 11:25
Practical Offering 3 Week(s) - 10 Wed 11:30 - 12:55
Practical Offering 3 Week(s) - 2 Wed 11:30 - 12:55
Practical Offering 3 Week(s) - 4 Wed 11:30 - 12:55
Practical Offering 3 Week(s) - 6 Wed 11:30 - 12:55
Practical Offering 3 Week(s) - 8 Wed 11:30 - 12:55
Practical Offering 4 Week(s) - 10 Thurs 11:30 - 12:55
Practical Offering 4 Week(s) - 2, 8 Thurs 11:30 - 12:55
Practical Offering 4 Week(s) - 4 Thurs 11:30 - 12:55
Practical Offering 4 Week(s) - 6 Thurs 11:30 - 12:55
Autumn