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Curricular information is subject to change
For part A, students will be able to:
- Relate important chemical and physical properties associated with transition metals to their roles in medicine and biology: (including oxidation state, d-electron configuration, CFSE, geometry, HSAB)
- Identify and classify interactions between metals and biological ligands, and recognise medicinal implications of metal ions in the body (toxicity, imbalance)
- Analyse and discuss the structure, activity and properties of selected metallodrugs against disease including cancer, rheumatoid arthritis, bacterial infection
-Analyse and discuss the use of metal complexes in medical imaging (Tc, Gd)
For part B, students learn about the general structure and functioning of metalloenzymes including the ligands that support the metals, i.e., porphyrins and amino-acids. Students learn about key biological molecules and how they integrate with metalloenzymes and the general mechanism by which the metalloenzyme operates, including redox properties and associated energy transport molecules. Finally, some key spectroscopic data that enabled chemists to identify key aspects of the mechanisms. Several organic transformation reactions vital to biological functioning are examined.
Metalloenzymes, chemical and physical properties of transition metals, metal-based drugs.
Student Effort Type | Hours |
---|---|
Lectures | 32 |
Tutorial | 4 |
Autonomous Student Learning | 72 |
Total | 108 |
This module is intended for students in the final year of an Honours Chemistry degree program or post graduate students in a Chemical discipline. Other students wishing to take this module must have a comparable background in chemistry and must consult the School.
Resit In | Terminal Exam |
---|---|
Spring | No |
• Group/class feedback, post-assessment
Trimester tests are graded with model solutions provided on Brightspace.
Name | Role |
---|---|
Dr Joseph Byrne | Lecturer / Co-Lecturer |
Lecture | Offering 1 | Week(s) - Autumn: All Weeks | Mon 12:00 - 12:50 |
Tutorial | Offering 1 | Week(s) - 13 | Thurs 10:00 - 11:50 |
Lecture | Offering 1 | Week(s) - Autumn: All Weeks | Thurs 11:00 - 11:50 |
Lecture | Offering 1 | Week(s) - Autumn: All Weeks | Tues 09:00 - 09:50 |