CHEM30200 Carbonyl Chemistry, Retrosynthesis and Synthetic Methods

Academic Year 2020/2021

This module advances the concepts of the chemical reactivity of the carbonyl group and hetroaromatic compounds with a specific emphasis placed on gaining an understanding of their different modes of reaction. In addition retrosynthetic analysis is introduced and a wide range of chemical transformations important in organic synthesis are discussed. This includes numerous examples of the application of the described chemistry to the making of complex chemical entities. Topic 1: Advanced Carbonyl Chemistry (9 lectures, 2 tutorials). Topic 2: Theory and Application of Retrosynthetic analysis (9 lectures, 2 tutorials). Topic 3: Laboratory Practical Course (8 sessions of 3 hours duration).

Due to the situation we all face with Covid-19 some of this module (Autumn Trimester 2020) will be delivered online. The situation will be assessed on an ongoing basis and as things progress during the summer. Our hope remains that we will deliver as much of this module in a face-to-face fashion, in the coming academic year, as possible.

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Curricular information is subject to change

Learning Outcomes:

On completion of this module students should have an understanding of:Acidity of Alpha, Beta, Gamma- hydrogens; enolate anion generation, stabilisation; keto/enol tautomerism; halogenation of acetone; alkylation of enolates; regioselctive formation of enolate anions; aldol reactions; claisen reactions; Michael addition chemistry; conjugate addition followed by aldol cyclization; Robinson annelation.Retrosynthetic analysis and how it can be useful in planning synthesis; the application of a range of reactions (nucleophilic substitution, electrophilic aromatic substitution, amide and ester synthesis, addition to carbonyl groups, reactions of nucleophiles with epoxides; reactions of enolates and enols; stereoselective synthesis of alkenes; ring closing and cross metathesis; diels Alder reaction; chemoselectivity and reactions of dianions, reduction of carbonyl compounds; catalytic hydrogenation; oxidation.Laboratory based synthetic organic chemistry with practical and analytical techniques.

Student Effort Hours: 
Student Effort Type Hours
Lectures

18
Tutorial

4
Laboratories

24
Autonomous Student Learning

54
Total

100
Approaches to Teaching and Learning:
Not yet recorded 
Requirements, Exclusions and Recommendations

Not applicable to this module.


Module Requisites and Incompatibles
Not applicable to this module.
 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Continuous Assessment: Two assessments will be set from the two main lecture material topics during the semester Varies over the Trimester n/a Standard conversion grade scale 40% No

10
Examination: Written examination 2 hour End of Trimester Exam Not specified Not yet recorded No

60
Lab Report: Laboratory, continuous assessment Varies over the Trimester n/a Not yet recorded No

30

Carry forward of passed components
Not yet recorded
 
Resit In Terminal Exam
Spring No
Please see Student Jargon Buster for more information about remediation types and timing. 
Not yet recorded
Name Role
Assoc Professor Marcus Baumann Lecturer / Co-Lecturer