CELB40190 Advanced Cancer Cell Biology and Genetics

Academic Year 2020/2021

This module covers advanced topics in the biology and genetics of cancer. Topics covered include the hallmarks of cancer, cancer epigenetics, cancer genomics, angiogenesis, invasion and metastases. Recent advances in targeted therapies will also be discussed. Students will have the opportunity to choose one "hot topic" to focus on in a workshop.

Show/hide contentOpenClose All

Curricular information is subject to change

Learning Outcomes:

On completion of this module, students should be able to:
1. Demonstrate an understanding of the universal hallmarks in the molecular pathogenesis of cancer.
2. Contrast the incidence and mortality of cancers from the developed and developing worlds.
3. Interpret modern research methodologies in cancer biology and genetics.
4. Critically evaluate research findings in cancer biology and genetics.
5. Discuss how discoveries in cancer research are advancing cancer medicine to impact patient care and survival across different parts of the world.
6. Recognise the potential impact of the environment and life choices on cancer development.
7.Identify research leaders in cancer cell biology and genetics from across the world.

Indicative Module Content:

1. The fundamental hallmarks of cancer: an overview
2. Cancer development: role of tumour suppressors & oncogenes
3. Cancer progression: angiogenesis, invasion & metastasis
4. Cancer genomics
5. Cancer epigenetics & epigenomics
6. The dark matter of cancer development: role of ncRNAs
7. Tumour microenvironment & heterogeneity
8. Altered signalling pathways in cancers of the developing & developed world
9. Liquid biopsies: circulating tumour cells, microvesicles & cell-free nucleic acids in cancer detection & management
10. The biology & genetics of cervical cancer
11. The biology & genetics of prostate cancer
12. Breakthroughs in cancer research in the developing & developed world

Student Effort Hours: 
Student Effort Type Hours
Lectures

12

Tutorial

3

Specified Learning Activities

10

Autonomous Student Learning

100

Total

125

Approaches to Teaching and Learning:
Online live lectures, which will also be recorded. peer and group discussions, problem-based learning, Cancer Cell webinars 
Requirements, Exclusions and Recommendations
Learning Recommendations:

Students should have a good understanding of cell biology and genetics.


Module Requisites and Incompatibles
Not applicable to this module.
 
Assessment Strategy  
Description Timing Open Book Exam Component Scale Must Pass Component % of Final Grade
Examination: Essay and short answer examination. 2 hour End of Trimester Exam No Graded No

80

Assignment: Students choose a webinar to view and write a short blog post. Throughout the Trimester n/a Graded No

20


Carry forward of passed components
Yes
 
Resit In Terminal Exam
Spring Yes - 2 Hour
Please see Student Jargon Buster for more information about remediation types and timing. 
Feedback Strategy/Strategies

• Feedback individually to students, post-assessment

How will my Feedback be Delivered?

Not yet recorded.

The Biology of Cancer, 2nd Ed
Robert A. Weinberg