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Curricular information is subject to change
On completion of this module students should be able to: 1. Understand how NMR, X-ray crystallography and electron microscopy can be used to determine biological strucures. 2. Utilise a range of biological techniques for examining protein-protein, protein-ligand and protein-DNA interactions. 3. Acquire a detailed understanding of how antibody-antigen, receptor-ligand and protein-protein interactions and can be applied to combat disease. 4. Understand how data on protein-DNA interactions are applied to understand biological functions at the genome level. 5. Understand the post translational processing of proteins and protein trafficking. 3. Determine catalytic constants kcat, KM, kcat/KM and the values of the inhibition constants Ki and IC50. 6. Measure pKa values in free enzymes and enzyme-substrate complexes. 7. Understand how enzymes can utilise transition state stabilisation, ground state stabilisation, nucleophilic, catalysis, electophilic catalysis, general acid-base calysis and binding/entropic catalysis to catalyse reactions. 8. Be aware of some of the ways ribozymes and catalytic antibodies can be used in medicine. 9. Utilise site directed mutagenesis to identify essential amino acids. 10. Protein design and industrial applications of mutagenesis experiments.
Student Effort Type | Hours |
---|---|
Lectures | 24 |
Practical | 15 |
Specified Learning Activities | 8 |
Autonomous Student Learning | 64 |
Total | 111 |
It is recommended that students taking this module have successfully completed BIOC20050 or other modules with equivalent learning outcomes.
Description | Timing | Component Scale | % of Final Grade | ||
---|---|---|---|---|---|
Continuous Assessment: Laboratory write ups | Throughout the Trimester | n/a | Graded | No | 15 |
Class Test: Class test | Throughout the Trimester | n/a | Graded | No | 15 |
Examination: Answer four questions in total, one question each from four sections | 2 hour End of Trimester Exam | No | Graded | No | 70 |
Resit In | Terminal Exam |
---|---|
Spring | Yes - 2 Hour |
• Feedback individually to students, post-assessment
• Group/class feedback, post-assessment
• Online automated feedback
Feedback will be available for all laboratory classes and their write ups. Calculations will also be conducted during the laboratory classes. This will help to answer the laboratory test at the end of the semester. This will further enhance the writing skills and calculations for the end semester exam.
Name | Role |
---|---|
Assoc Professor Gerard Cagney | Lecturer / Co-Lecturer |
Assoc Professor Margaret Worrall | Lecturer / Co-Lecturer |
Ms Maeve Boyce | Tutor |
Ms Caoimbhe Burke | Tutor |
Ms Niamh Duggan | Tutor |
Miss Ella Fouhy | Tutor |
Ms Manushak Hovsepyan | Tutor |
Yanqiu Ye | Tutor |
Practical | Offering 1 | Week(s) - 10 | Mon 10:00 - 12:50 |
Practical | Offering 1 | Week(s) - 12 | Mon 10:00 - 12:50 |
Practical | Offering 1 | Week(s) - 3, 5 | Mon 10:00 - 12:50 |
Practical | Offering 1 | Week(s) - 9 | Mon 10:00 - 12:50 |
Lecture | Offering 1 | Week(s) - Autumn: All Weeks | Thurs 15:00 - 15:50 |
Lecture | Offering 1 | Week(s) - Autumn: All Weeks | Tues 16:00 - 16:50 |